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Southern Fried Chicken with Creamy Cajun Sauce: The Kind of Meal Folks Remember

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Alright, let’s be honest — fried chicken is more than just food down here in the South. It’s love. It’s tradition. It’s that sound of hot oil popping while kids run in and out the back door and someone’s hollering, “Don’t let the flies in!”

This recipe takes that good ol’ crispy fried chicken and dresses it up a bit — with a creamy Cajun sauce that’ll have you sopping your plate clean with a biscuit. It’s the kind of meal that makes folks go quiet around the table, because everyone’s too busy eating. And truth be told, that’s the best compliment you can get.

Why You’ll Want to Make This Again (and Again)

  • Crunchy, golden crust that stays crispy even under gravy.

  • Cajun cream sauce that’s bold, a little spicy, and downright addictive.

  • Simple ingredients you probably already have on hand.

  • Brings people together — and isn’t that the whole point?

The Ingredients (Nothing Fancy, Promise)

  • Chicken – Thighs and drumsticks are my pick (juicier, cheaper, tastier).

  • Buttermilk – Tenderizes and seasons. No buttermilk? Mix milk with a spoonful of vinegar. Easy fix.

  • Flour + Spices – Paprika, garlic powder, onion powder, salt, pepper, cayenne. That’s your crunchy coating.

  • Oil – Just plain vegetable oil. Don’t overthink it.

  • Heavy Cream + Cajun Seasoning – This is where the magic sauce happens.

  • Butter & Parsley – One makes it rich, the other makes it pretty.

How to Make It (Like We’re Cooking Side by Side)

1. Give That Chicken a Bath

Put your chicken in a big bowl, cover with buttermilk, and let it chill in the fridge. Two hours is good, overnight is better. The buttermilk works like a charm — makes it tender and juicy.

2. Season the Dredge

Mix flour and your spices in a shallow dish. Taste the flour with a wet finger (yep, old trick) — if it tastes seasoned, your chicken will too.

3. Coat Each Piece

Pull the chicken out of the buttermilk, let the extra drip off, then roll it around in the flour mix until every little nook is coated.

4. Fry It Up

Heat oil in a skillet (cast iron if you’ve got one) to about 350°F. Fry the chicken in batches, turning here and there, for 12–15 minutes or until golden brown. Don’t crowd the pan or you’ll end up steaming instead of frying. Drain on paper towels.

5. Make the Sauce While You Wait

Melt butter in a small pan, stir in Cajun seasoning until it smells amazing, then pour in the heavy cream. Keep stirring until it thickens a bit. That’s it — easy as pie.

6. Bring It Together

Pile the chicken on a platter, drizzle that creamy sauce over the top, and sprinkle parsley if you feel like making it look fancy.

Tips & Variations (Because Everyone Cooks Different)

  • Want it hotter? Add hot sauce to the buttermilk or more cayenne to the flour.

  • Want it lighter? Use half cream, half chicken broth.

  • Gluten-free? Just use your favorite GF flour mix.

  • Got mushrooms? Toss them in the sauce for a little earthy flavor.

Leftovers (If That’s Even a Thing)

If somehow you don’t eat it all, tuck it in the fridge for up to 3 days. Reheat in the oven at 350°F so the crust gets crispy again. Sauce can be rewarmed gently on the stove — add a splash of cream or broth if it feels too thick.

Freezing works too, but honestly? Fried chicken’s at its best fresh from the skillet.

Final Thoughts from My Table

This ain’t fancy food. This is food that makes you loosen your belt and lean back in your chair, smiling at the folks you’re sharing it with. That’s Southern cooking — it feeds your belly and your soul.

If you make this, promise me you’ll sit down, pour a glass of sweet tea, and really enjoy it. That’s what it’s for. And if you’ve got a family fried chicken trick up your sleeve? Leave it in the comments — I’d love to hear how y’all do it.

Southern Fried Chicken with Creamy Cajun Sauce

This Southern Fried Chicken with Creamy Cajun Sauce is the perfect harmony of crunchy, golden-fried chicken paired with a velvety, spiced cream sauce. It’s Sunday supper comfort with a bold Cajun twist that’ll have everyone asking for seconds.
Prep Time 20 minutes
Cook Time 30 minutes
Total Time 50 minutes
Course Main Dish
Cuisine Cajun, Southern
Servings 4
Calories 620 kcal

Ingredients
  

  • 4 chicken thighs
  • 4 chicken drumsticks
  • 2 cups buttermilk
  • 2 cups all-purpose flour
  • 1 tablespoon paprika
  • 1 teaspoon garlic powder
  • 1 teaspoon onion powder
  • 1 teaspoon salt
  • 1/2 teaspoon black pepper
  • 1/2 teaspoon cayenne pepper
  • vegetable oil for frying
  • 1 cup heavy cream
  • 1 tablespoon Cajun seasoning
  • 1 tablespoon butter
  • 1 tablespoon chopped parsley

Instructions
 

  • Place chicken thighs and drumsticks in a large bowl. Pour buttermilk over the chicken, cover, and refrigerate for at least 2 hours or overnight.
  • In a separate bowl, mix together flour, paprika, garlic powder, onion powder, salt, black pepper, and cayenne pepper.
  • Remove chicken from buttermilk and let excess drip off. Dredge each piece thoroughly in the seasoned flour mixture.
  • Heat vegetable oil in a deep skillet or fryer to 350°F (175°C).
  • Fry chicken in batches, turning occasionally, for 12–15 minutes per batch, or until golden brown and cooked through. Drain on paper towels.
  • For the sauce: In a small saucepan, melt butter over medium heat. Add Cajun seasoning and stir for 1 minute.
  • Pour in heavy cream and bring to a simmer, stirring constantly, until sauce thickens slightly.
  • Serve fried chicken hot, drizzled with Cajun cream sauce. Garnish with chopped parsley.

Notes

This recipe pairs beautifully with mashed potatoes, collard greens, or a buttery biscuit. For an extra spicy kick, add a dash of hot sauce to the cream sauce or a pinch more cayenne to the flour mix.

Nutrition

Calories: 620kcal
Keyword buttermilk chicken, cajun sauce, fried chicken, southern comfort food
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